The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps cause an increase in methadone plasma concentrations, which could induce possibly lethal respiratory despair. Moreover, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19